Chapter+4

toc =Page 50= 1. Increasing concentration of HgCl2 at low concentrations does not have a significant effect; As concentration increases, BUN rises/significant rise in BUN between 30 and 40 umol/kg;

2. a) at 20 umol/kg there is a significant difference in BUN between null and wild type mice; at 30 umol/kg there is very large significant difference in BUN between null and wild type mice; at 40 umol per kg wild type mice still lower BUN then null type at 30 umol per kg /40 umol per kg is lethal to null mice but not control mice; suggests that metallothionein is somehow able to neutralize effects of HgCl2; b) bind to Hg so that it has no effect on metabolism (this is what it actually does -- given that this is a 'suggest' question, other reasonable answers would be accepted even if they weren't actually what happened).

3. Possible answers: From an absolutist perspective, no additional information is required as it is never acceptable to treat animals in this way. From a consequentialist perspective, the experiment is justified if the outcome leads to a strategy to solve environmental toxicology challenges. From a motivist perspective, the experiment is justified even if the experiment doesn't lead to a useful outcome as long as the experiment was intended to lead to a useful outcome.